Robin van Persie leads the way in the scoring charts with 16 goals this season to Luis Suarez's 15, but the visitors face a tough task against a side unbeaten in seven at home.
Wayne Rooney is unlikely to feature due to a knee problem, having only just returned to training. Elsewhere, Phil Jones (knock) is also back in training but unlikely to play, while Anderson and Nani (both hamstring) could be in the squad for Sunday, but look set to feature from the bench, if at all.
For the visitors, Jose Enrique (hamstring) is likely to be out until February following his injury against QPR, so Stewart Downing could make an appearance in his place, otherwise Andre Wisdom could come into the side at right-back, with Glen Johnson slotting in on the left side.
Martin Kelly (knee) remains a long-term absentee, as does Fabio Borini (broken foot), though the striker is due back soon.