James Milner missed a second half penalty as a dominante Liverpool side could only manage a 0 - 0 draw against Southampton at Anfield.
Up until the penalty in the 64th minute, Jurgen Klopp had few chances on target with COutinho and Origi missed good chances.
The Saints came to Anfield to defend and that showed in their stats which they failed to get a shot on target.
Milner had converted his seven spot-kicks from seven this season, but he was unable to preserve his perfect record as Fraser Forster saved brilliantly to his bottom right.
Liverpool remained in third with two games to play left to play before the end of the season but Manchester City are one point in arrears with a game in hand.
Manchester United are five points behind the Reds in fifth before facing Arsenal later on Sunday the first of four remaining league games for Jose Mourinho's men this term.
This means Liverpool have to play City and United drop points to have any chance of making Europe.
Southampton moved up to 10th, ahead of Bournemouth and West Ham on goal difference, with their boss Claude Puel extending an unbeaten career record against Liverpool to six matches.