Manchester United are looking to win the only title in Europe that has so far eluded them.
Jose Mourinho's side have Paul Pogba, Eric Bailly, Phil Jones and Chris Smalling back from injury, but Juan Mata is still unavailable for selection.
Celta Vigo and Manchester United are meeting for first time, but Celta's record vs English sides reads W5 D0 L4.
United have won just twice away to Spanish opponents in 22 attempts, but are currently unbeaten in eight UEFA Europa League games (W6 D2).
The Spanish side are playing in their first ever European semi-final and have lost their last three games.
They have also won just two of their last eight games in all competitions while United are unbeaten in 11 matches, winning six of them
Celta: Sergio Álvarez; Mallo, Cabral, Fontàs, Jonny; Radoja, Pablo Hernández; Aspas, Wass, Sisto; Guidetti.
Out: Rossi (knee), Planas (knee)
Manchester United: Romero; Valencia, Bailly, Darmian, Young; Pogba, Carrick, Herrera; Mkhitaryan, Rashford, Martial.
Out: Shaw (ankle), Ibrahimović (knee), Rojo (knee)