Sevilla, Juventus, Leicester City and FC Porto are the teams hoping to join the likes of Barcelona, Bayern Munich in the Champions League quarter-finals.
The four mentioned have played their first leg round of 16 clash; Sevilla won 2 - 1 in Seville while Juventus defeated Porto in Portugal, thanks to two goals from Pjaca and Dani Alves.
We preview the matches to be played tonight in Europe's top competition;
Juventus vs Porto
The odds are in Juventus's favour going into the second leg, but coach Massimiliano Allegri is wary of a Porto side that have won 3-0 in Italy already this season.
Italian champions boast 100% record in UEFA ties after winning away first leg but Porto have won four of their 13 away games against Italian clubs
The Portuguese side won 3-0 at Roma in this season's play-off, but Juve are targeting tenth quarter-final but just a third in last seven attempts.
Porto meanwhile are aiming to reach last eight for seventh time in their history.
Juventus: Buffon; Lichtsteiner, Barzagli, Bonucci, Alex Sandro; Marchisio, Khedira; Cuadrado, Dybala, Mandžukić; Higuaín.
Doubtful: Chiellini (thigh)
Out: Sturaro (stomach)
Misses next match if booked: none
Porto: Casillas; Maxi Pereira, Marcano, Felipe, Layún; Danilo, André André, Óliver Torres; Brahimi, André Silva, Soares.
Out: Telles (suspended)
Misses next match if booked: Felipe, André Silva, Marcano, Herrera
Leicester City vs Sevilla
Sevilla hold a 2-1 advantage from the first leg in Spain. Joaquin Correa and Pablo Sarabia grabbed the goals for the Spanish side while Jamie Vardy netted an important away goal.
English champions have won all three of their home games in the competition this season whule the visitors are unbeaten in eight games in all competitions
Leicester: Schmeichel; Simpson, Morgan, Huth, Fuchs; Mahrez, Drinkwater, Ndidi, Albrighton; Okazaki, Vardy.
Out: Mendy (knee), Wague (shoulder)
Misses next match if booked: Huth, Slimani
Sevilla: Rico; Pareja, Rami, Mercado; Mariano, N'Zonzi, Nasri, Escudero; Iborra; Jovetić, Vitolo.
Out: Trémoulinas (knee), Vietto (not in squad), Carriço (not in squad)
Misses next match if booked: Iborra, Pareja