Arsenal winners in 2014 and 2015 will travel to Sutton United in the FA Cup fifth round.
The Gunners were paired with the non-league side who sensationally knocked out Leeds in the last round.
Fellow non-leaguers Lincoln City also pulled a Premier League side out of the hat and will travel to Turf Moor to take on Burnley.
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Manchester United face former Premier League side Blackburn as they bid to retain the trophy they won last season, while Premier League table-toppers Chelsea go to Molineux to face Liverpool's conquerors, Wolves.
United's neighbours Man City also have an away tie at a Championship side, travelling to David Wagner's Huddersfield.
Below are the games to be played in the fifth round/round off 16.
Burnley vs Lincoln City
Fulham vs Tottenham
Blackburn vs Man United
Middlesbrough vs Oxford United
Sutton vs Arsenal
Wolves vs Chelsea
Huddersfield vs Man City
Millwall vs Derby/Leicester